Vanessa Schmithorst

MR Physicist (Ph.D)

UPMC Children's Hospital of Pittsburgh

4401 Penn Avenue - Room 2539D; Pittsburgh, PA


EDUCATION and TRAINING

UNDERGRADUATE:

9/84 – 8/89         University of Cincinnati, Cincinnati, OH   Bachelor of Science, 1989                              Physics

Bachelor of Music, 1989                                 Piano

GRADUATE:

9/92 – 8/97         University of Cincinnati, Cincinnati, OH   Master of Science, 1994                                 Physics

Doctor of Philosophy, 1997                          Physics

APPOINTMENTS and POSITIONS

ACADEMIC:

1997 – 2002        Children’s Hospital, Cincinnati, OH            Post-Doctoral Research Associate

2002 – 2009        Children’s Hospital, Cincinnati, OH            Research Assistant Professor

2009 – 2011        Children’s Hospital, Cincinnati, OH            Research Associate Professor

2011 – Present Children’s Hospital, Pittsburgh, PA            Research Associate Professor

Director, Pediatric Imaging Research Center

MEMBERSHIP in PROFESSIONAL and SCIENTIFIC SOCIETIES

International Society for Magnetic Resonance in Medicine            2002 – Present

Organization for Human Brain Mapping                                                 2007 – Present

HONORS

Editors Choice Award, presented by the Organization for Human Brain Mapping for Best Paper in the Cognitive Neuroscience Section of NeuroImage:                                    2006

PUBLICATIONS

Refereed articles

  1. Lee J, Mawla I, Kim J, Loggia ML, Ortiz A, Jung C, Chan ST, Gerber J, Schmithorst VJ, Edwards RR, Wasan AD, Berna C, Kong J, Kaptchuk TJ, Gollub RL, Rosen BR, Napadow V. Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics. Pain. 2019;160(3):550-60. PubMed PMID: 30540621; PubMed Central PMCID: PMC6377310.
  2. Schmithorst VJ, Votava-Smith JK, Tran N, Kim R, Lee V, Ceschin R, Lai H, Johnson JA, De Toledo JS, Bluml S, Paquette L, Panigrahy A. Structural network topology correlates of microstructural brain dysmaturation in term infants with congenital heart disease. Hum Brain Mapp. 2018;39(11):4593-610. PubMed PMID: 30076775; PubMed Central PMCID: PMC6260793.
  3. Hanford LC, Schmithorst VJ, Panigrahy A, Lee V, Ridley J, Bonar L, Versace A, Hipwell AE, Phillips ML. The Impact of Caregiving on the Association Between Infant Emotional Behavior and Resting State Neural Network Functional Topology. Front Psychol. 2018;9:1968. PubMed PMID: 30374323; PubMed Central PMCID: PMC6196255.
  4. Harbison AL, Votava-Smith JK, Del Castillo S, Kumar SR, Lee V, Schmithorst V, Lai HA, O’Neil S, Bluml S, Paquette L, Panigrahy A. Clinical Factors Associated with Cerebral Metabolism in Term Neonates with Congenital Heart Disease. J Pediatr. 2017;183:67-73 e1. PubMed PMID: 28109537; PubMed Central PMCID: PMC5368020.
  5. Mawla I, Loggia M, Schmithorst V, Ortiz A, Gerber J, Protsenko E, Lee J, Kim J, Kim H, Berna C, Kaptchuk T, Kong J, Gollub R, Rosen B, Edwards R, Wasan A, Napadow V. (336) Investigating the neural circuitry supporting clinical pain perception in chronic low back pain – the importance of cardiorespiratory artifact correction with arterial spin labeling fMRI. J Pain. 2016;17(4S):S59-S60. PubMed PMID: 28162572.
  6. Schmithorst VJ, Panigrahy A, Gaynor JW, Watson CG, Lee V, Bellinger DC, Rivkin MJ, Newburger JW. Organizational topology of brain and its relationship to ADHD in adolescents with d-transposition of the great arteries. Brain Behav. 2016;6(8):e00504. PubMed PMID: 27547505; PubMed Central PMCID: PMC4980474.
  7. Manchester LC, Lee V, Schmithorst V, Kochanek PM, Panigrahy A, Fink EL. Global and Regional Derangements of Cerebral Blood Flow and Diffusion Magnetic Resonance Imaging after Pediatric Cardiac Arrest. J Pediatr. 2016;169:28-35 e1. PubMed PMID: 26561380; PubMed Central PMCID: PMC4729616.
  8. Ceschin R, Lee VK, Schmithorst V, Panigrahy A. Regional vulnerability of longitudinal cortical association connectivity: Associated with structural network topology alterations in preterm children with cerebral palsy. Neuroimage Clin. 2015;9:322-37. PubMed PMID: 26509119; PubMed Central PMCID: PMC4588423.
  9. Degnan AJ, Wisnowski JL, Choi S, Ceschin R, Bhushan C, Leahy RM, Corby P, Schmithorst VJ, Panigrahy A. Altered Structural and Functional Connectivity in Late Preterm Preadolescence: An Anatomic Seed-Based Study of Resting State Networks Related to the Posteromedial and Lateral Parietal Cortex. PLoS One. 2015;10(6):e0130686. PubMed PMID: 26098888; PubMed Central PMCID: PMC4476681.
  10. Tocchio S, Kline-Fath B, Kanal E, Schmithorst VJ, Panigrahy A. MRI evaluation and safety in the developing brain. Semin Perinatol. 2015;39(2):73-104. PubMed PMID: 25743582; PubMed Central PMCID: PMC4380813.
  11. Panigrahy A, Schmithorst VJ, Wisnowski JL, Watson CG, Bellinger DC, Newburger JW, Rivkin MJ. Relationship of white matter network topology and cognitive outcome in adolescents with d-transposition of the great arteries. Neuroimage Clin. 2015;7:438-48. PubMed PMID: 25685710; PubMed Central PMCID: PMC4318874.
  12. Wisnowski JL, Ceschin RC, Choi SY, Schmithorst VJ, Painter MJ, Nelson MD, Bluml S, Panigrahy A. Reduced thalamic volume in preterm infants is associated with abnormal white matter metabolism independent of injury. Neuroradiology. 2015;57(5):515-25. PubMed PMID: 25666231; PubMed Central PMCID: PMC4405472.
  13. Degnan AJ, Wisnowski JL, Choi S, Ceschin R, Bhushan C, Leahy RM, Corby P, Schmithorst VJ, Panigrahy A. Alterations of resting state networks and structural connectivity in relation to the prefrontal and anterior cingulate cortices in late prematurity. Neuroreport. 2015;26(1):22-6. PubMed PMID: 25426826.
  14. Schmithorst VJ, Vannest J, Lee G, Hernandez-Garcia L, Plante E, Rajagopal A, Holland SK. Evidence that neurovascular coupling underlying the BOLD effect increases with age during childhood. Hum Brain Mapp. 2015;36(1):1-15. PubMed PMID: 25137219.
  15. Wisnowski JL, Schmithorst VJ, Rosser T, Paquette L, Nelson MD, Haynes RL, Painter MJ, Bluml S, Panigrahy A. Magnetic resonance spectroscopy markers of axons and astrogliosis in relation to specific features of white matter injury in preterm infants. Neuroradiology. 2014;56(9):771-9. PubMed PMID: 24903580.
  16. Farah R, Schmithorst VJ, Keith RW, Holland SK. Altered white matter microstructure underlies listening difficulties in children suspected of auditory processing disorders: a DTI study. Brain Behav. 2014;4(4):531-43. PubMed PMID: 25161820; PubMed Central PMCID: PMC4128035.
  17. Degnan AJ, Ceschin R, Lee V, Schmithorst VJ, Bluml S, Panigrahy A. Early metabolic development of posteromedial cortex and thalamus in humans analyzed via in vivo quantitative magnetic resonance spectroscopy. J Comp Neurol. 2014;522(16):3717-32. PubMed PMID: 24888973; PubMed Central PMCID: PMC4193612.
  18. Schmithorst VJ, Plante E, Holland S. Unilateral deafness in children affects development of multi-modal modulation and default mode networks. Front Hum Neurosci. 2014;8:164. PubMed PMID: 24723873; PubMed Central PMCID: PMC3971169.
  19. Schmithorst VJ, Farah R, Keith RW. Left ear advantage in speech-related dichotic listening is not specific to auditory processing disorder in children: A machine-learning fMRI and DTI study. Neuroimage Clin. 2013;3:8-17. PubMed PMID: 24179844; PubMed Central PMCID: PMC3791276.
  20. Schmithorst VJ, Hernandez-Garcia L, Vannest J, Rajagopal A, Lee G, Holland SK. Optimized simultaneous ASL and BOLD functional imaging of the whole brain. J Magn Reson Imaging. 2013. PubMed PMID: 24115454; PubMed Central PMCID: PMC3964152.
  21. Szaflarski JP, Rajagopal A, Altaye M, Byars AW, Jacola L, Schmithorst VJ, Schapiro MB, Plante E, Holland SK. Left-handedness and language lateralization in children. Brain Res. 2012;1433:85-97. PubMed PMID: 22177775; PubMed Central PMCID: PMC3249496.
  22. Jacola LM, Byars AW, Chalfonte-Evans M, Schmithorst VJ, Hickey F, Patterson B, Hotze S, Vannest J, Chiu CY, Holland SK, Schapiro MB. Functional magnetic resonance imaging of cognitive processing in young adults with Down syndrome. Am J Intellect Dev Disabil. 2011 Sep;116(5):344-59. PubMed PMID: 21905803.
  23. Szaflarski JP, Rajagopal A, Altaye M, Byars AW, Jacola L, Schmithorst VJ, Schapiro MB, Plante E, Holland SK. Left-handedness and language lateralization in children. Brain Res. 2012 Jan 18;1433:85-97. Epub 2011 Nov 28. PubMed PMID: 22177775; PubMed Central PMCID: PMC3249496.
  24. Tkach JA, Chen X, Freebairn LA, Schmithorst VJ, Holland SK, Lewis BA. Neural correlates of phonological processing in speech sound disorder: a functional magnetic resonance imaging study. Brain Lang. 2011 Oct;119(1):42-9. Epub 2011 Apr 1. PubMed PMID: 21458852; PubMed Central PMCID: PMC3162995.
  25. Schmithorst VJ, Holland SK, Plante E. Diffusion tensor imaging reveals white matter microstructure correlations with auditory processing ability. Ear Hear. 2011 Mar-Apr;32(2):156-67. PubMed PMID: 21063207; PubMed Central PMCID: PMC3057932.
  26. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A linear structural equation model for covert verb generation based on independent component analysis of FMRI data from children and adolescents. Front Syst Neurosci. 2011;5:29. Epub 2011 Jun 1. PubMed PMID: 21660108; PubMed Central  PMCID: PMC3106180.
  27. Vannest J, Rasmussen J, Eaton KP, Patel K, Schmithorst V, Karunanayaka P, Plante E, Byars A, Holland S. FMRI activation in language areas correlates with verb generation performance in children. 2010 Oct;41(5):235-9. Epub 2011 Jan 5. PubMed PMID: 21210340.
  28. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study. Neuroimage. 2010 May 15;51(1):472-87. Epub 2010 Jan 4. PubMed PMID: 20056150.
  29. Propst EJ, Greinwald JH, Schmithorst V. Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 2010 Jan;136(1):22-6. PubMed PMID: 20083773.
  30. Brubaker CJ, Schmithorst VJ, Haynes EN, Dietrich KN, Egelhoff JC, Lindquist DM, Lanphear BP, Cecil KM. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009 Nov;30(6):867-75. Epub 2009 Jul 18. PubMed PMID: 19619581; PubMed Central PMCID: PMC2789851.
  31. Köhler A, Schmithorst V, Filippi MD, Ryan MA, Daria D, Gunzer M, Geiger H. Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones. Blood. 2009 Jul 9;114(2):290-8. Epub 2009 Apr 8. PubMed PMID: 19357397; PubMed Central PMCID: PMC2714205.
  32. Yuan W, Altaye M, Ret J, Schmithorst V, Byars AW, Plante E, Holland SK. Quantification of head motion in children during various fMRI language tasks. Hum Brain Mapp. 2009 May;30(5):1481-9. PubMed PMID: 18636549; PubMed Central PMCID: PMC2763570.
  33. Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, Dardzinski BJ, Brody AS. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR Am J Roentgenol. 2009 Apr;192(4):1037-44. PubMed PMID: 19304711.
  34. Vannest JJ, Karunanayaka PR, Altaye M, Schmithorst VJ, Plante EM, Eaton KJ, Rasmussen JM, Holland SK. Comparison of fMRI data from passive listening and active-response story processing tasks in children. J Magn Reson Imaging. 2009 Apr;29(4):971-6. PubMed PMID: 19306445; PubMed Central PMCID: PMC2763568.
  35. Schmithorst VJ. Developmental Sex Differences In The Relation Of Neuroanatomical Connectivity To Intelligence. Intelligence. 2009 Mar;37(2):164-173. PubMed PMID: 21297966; PubMed Central PMCID: PMC3032174.
  36. Huang L, Thompson EA, Schmithorst V, Holland SK, Talavage TM. Partially adaptive STAP algorithm approaches to functional MRI. IEEE Trans Biomed Eng. 2009 Feb;56(2):518-21. Epub 2008 Oct 3. PubMed PMID: 19272913; PubMed Central PMCID: PMC2904987.
  37. Schmithorst VJ. Higher-order contrast functions improve performance of independent component analysis of fMRI data. J Magn Reson Imaging. 2009 Jan;29(1):242-9. PubMed PMID: 19097110; PubMed Central PMCID: PMC2653629.
  38. Tillema JM, Byars AW, Jacola LM, Schapiro MB, Schmithorst VJ, Szaflarski JP, Holland SK. Reprint of “Cortical reorganization of language functioning following perinatal left MCA stroke” [Brain and Language 105 (2008) 99-111]. Brain Lang. 2008 Sep;106(3):184-94. PubMed PMID: 18762059.
  39. Schmithorst VJ, Holland SK, Dardzinski BJ. Developmental differences in white matter architecture between boys and girls. Hum Brain Mapp. 2008 Jun;29(6):696-710. PubMed PMID: 17598163; PubMed Central PMCID: PMC2396458.
  40. Tillema JM, Byars AW, Jacola LM, Schapiro MB, Schmithorst VJ, Szaflarski JP, Holland SK. Cortical reorganization of language functioning following perinatal left MCA stroke. Brain Lang. 2008 May;105(2):99-111. Epub 2007 Oct 1. PubMed PMID: 17905426; PubMed Central PMCID: PMC2763390.
  41. Espay AJ, Schmithorst VJ, Szaflarski JP. Chronic isolated hemifacial spasm as a manifestation of epilepsia partialis continua. Epilepsy Behav. 2008 Feb;12(2):332-6. Epub 2007 Oct 24. PubMed PMID: 17951112; PubMed Central PMCID: PMC2235813.
  42. Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med. 2008 Jan 10;358(2):140-51. PubMed PMID: 18184959.
  43. Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL. Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1919-25. Epub 2007 Sep 28. PubMed PMID: 17905895.
  44. Schmithorst VJ, Holland SK, Plante E. Object identification and lexical/semantic access in children: a functional magnetic resonance imaging study of word-picture matching. Hum Brain Mapp. 2007 Oct;28(10):1060-74. PubMed PMID: 17133401; PubMed Central PMCID: PMC2763496.
  45. Schmithorst VJ, Holland SK, Plante E. Development of effective connectivity for narrative comprehension in children. Neuroreport. 2007 Sep 17;18(14):1411-5. PubMed PMID: 17712265; PubMed Central PMCID: PMC2762809.
  46. Holland SK, Vannest J, Mecoli M, Jacola LM, Tillema JM, Karunanayaka PR, Schmithorst VJ, Yuan W, Plante E, Byars AW. Functional MRI of language lateralization during development in children. Int J Audiol. 2007 Sep;46(9):533-51. PubMed PMID: 17828669; PubMed Central PMCID: PMC2763431.
  47. Patel AM, Cahill LD, Ret J, Schmithorst V, Choo D, Holland S. Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation. Arch Otolaryngol Head Neck Surg. 2007 Jul;133(7):677-83. PubMed PMID: 17638781; PubMed Central PMCID: PMC2763405.
  48. Schmithorst VJ, Holland SK. Sex differences in the development of neuroanatomical functional connectivity underlying intelligence found using Bayesian connectivity analysis. Neuroimage. 2007 Mar;35(1):406-19. Epub 2007 Jan 12. PubMed PMID: 17223578; PubMed Central PMCID: PMC2100392.
  49. Karunanayaka PR, Holland SK, Schmithorst VJ, Solodkin A, Chen EE, Szaflarski JP, Plante E. Age-related connectivity changes in fMRI data from children listening to stories. Neuroimage. 2007 Jan 1;34(1):349-60. Epub 2006 Oct 24. PubMed PMID: 17064940.
  50. Wilke M, Schmithorst VJ. A combined bootstrap/histogram analysis approach for computing a lateralization index from neuroimaging data. Neuroimage. 2006 Nov 1;33(2):522-30. Epub 2006 Aug 30. PubMed PMID: 16938470.
  51. Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, Degen JL, Davis RJ, Mizushima N, Rakic P, Dardzinski BJ, Holland SK, Sharp FR, Kuan CY. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol. 2006 Aug;169(2):566-83. PubMed PMID: 16877357; PubMed Central PMCID: PMC1780162.
  52. Schmithorst VJ, Holland SK. Functional MRI evidence for disparate developmental processes underlying intelligence in boys and girls. Neuroimage. 2006 Jul 1;31(3):1366-79. Epub 2006 Mar 15. PubMed PMID: 16540350.
  53. Plante E, Holland SK, Schmithorst VJ. Prosodic processing by children: an fMRI study. Brain Lang. 2006 Jun;97(3):332-42. Epub 2006 Feb 7. PubMed PMID: 16460792; PubMed Central PMCID: PMC1463022.
  54. Szaflarski JP, Schmithorst VJ, Altaye M, Byars AW, Ret J, Plante E, Holland SK. A longitudinal functional magnetic resonance imaging study of language development in children 5 to 11 years old. Ann Neurol. 2006 May;59(5):796-807. PubMed PMID: 16498622; PubMed Central PMCID: PMC2265796.
  55. Yuan W, Szaflarski JP, Schmithorst VJ, Schapiro M, Byars AW, Strawsburg RH, Holland SK. fMRI shows atypical language lateralization in pediatric epilepsy patients. Epilepsia. 2006 Mar;47(3):593-600. PubMed PMID: 16529628; PubMed Central PMCID: PMC1402337.
  56. Szaflarski JP, Holland SK, Schmithorst VJ, Byars AW. fMRI study of language lateralization in children and adults. Hum Brain Mapp. 2006 Mar;27(3):202-12. PubMed PMID: 16035047; PubMed Central PMCID: PMC1464420.
  57. Adler CM, Adams J, DelBello MP, Holland SK, Schmithorst V, Levine A, Jarvis K, Strakowski SM. Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study. Am J Psychiatry. 2006 Feb;163(2):322-4. PubMed PMID: 16449490.
  58. Jacola LM, Schapiro MB, Schmithorst VJ, Byars AW, Strawsburg RH, Szaflarski JP, Plante E, Holland SK. Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke. Neuropediatrics. 2006 Feb;37(1):46-52. PubMed PMID: 16541368; PubMed Central PMCID: PMC1859843.
  59. Chiu CY, Schmithorst VJ, Brown RD, Holland SK, Dunn S. Making memories: a cross-sectional investigation of episodic memory encoding in childhood using FMRI. Dev Neuropsychol. 2006;29(2):321-40. PubMed PMID: 16515409.
  60. Schmithorst VJ, Holland SK, Plante E. Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study. Neuroimage. 2006 Jan 1;29(1):254-66. Epub 2005 Aug 18. PubMed PMID: 16109491; PubMed Central PMCID: PMC1357541.
  61. Plante E, Schmithorst VJ, Holland SK, Byars AW. Sex differences in the activation of language cortex during childhood. Neuropsychologia. 2006;44(7):1210-21. Epub 2005 Nov 21. PubMed PMID: 16303148.
  62. Adler CM, Delbello MP, Mills NP, Schmithorst V, Holland S, Strakowski SM. Comorbid ADHD is associated with altered patterns of neuronal activation in adolescents with bipolar disorder performing a simple attention task. Bipolar Disord. 2005 Dec;7(6):577-88. PubMed PMID: 16403183.
  63. Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK. Cognitive functions correlate with white matter architecture in a normal pediatric population: a diffusion tensor MRI study. Hum Brain Mapp. 2005 Oct;26(2):139-47. PubMed PMID: 15858815; PubMed Central PMCID: PMC1859842.
  64. Chiu CY, Coen-Cummings M, Schmithorst VJ, Holland SK, Keith R, Nabors L, Kramer M, Rozier H. Sound blending in the brain: a functional magnetic resonance imaging investigation. Neuroreport. 2005 Jun 21;16(9):883-6. PubMed PMID: 15931055.
  65. Schmithorst VJ, Holland SK, Ret J, Duggins A, Arjmand E, Greinwald J. Cortical reorganization in children with unilateral sensorineural hearing loss. Neuroreport. 2005 Apr 4;16(5):463-7. PubMed PMID: 15770152; PubMed Central PMCID: PMC1357558.
  66. Schmithorst VJ. Separate cortical networks involved in music perception: preliminary functional MRI evidence for modularity of music processing. Neuroimage. 2005 Apr 1;25(2):444-51. PubMed PMID: 15784423.
  67. Schapiro MB, Schmithorst VJ, Wilke M, Byars AW, Strawsburg RH, Holland SK. BOLD fMRI signal increases with age in selected brain regions in children. Neuroreport. 2004 Dec 3;15(17):2575-8. PubMed PMID: 15570155; PubMed Central PMCID: PMC1351216.
  68. Adler CM, Holland SK, Schmithorst V, Tuchfarber MJ, Strakowski SM. Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disord. 2004 Dec;6(6):540-9. PubMed PMID: 15541070.
  69. Thompson EA, Holland SK, Schmithorst VJ. A STAP algorithm approach to fMRI: a simulation study. J Magn Reson Imaging. 2004 Oct;20(4):715-22. PubMed PMID: 15390141.
  70. Schmithorst VJ, Brown RD. Empirical validation of the triple-code model of numerical processing for complex math operations using functional MRI and group Independent Component Analysis of the mental addition and subtraction of fractions. Neuroimage. 2004 Jul;22(3):1414-20. PubMed PMID: 15219612.
  71. Adler CM, Holland SK, Schmithorst V, Wilke M, Weiss KL, Pan H, Strakowski SM. Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord. 2004 Jun;6(3):197-203. PubMed PMID: 15117398.
  72. Szaflarski JP, Holland SK, Schmithorst VJ, Dunn RS, Privitera MD. High-resolution functional MRI at 3T in healthy and epilepsy subjects: hippocampal activation with picture encoding task. Epilepsy Behav. 2004 Apr;5(2):244-52. PubMed PMID: 15123027.
  73. Schmithorst VJ, Holland SK. Comparison of three methods for generating group statistical inferences from independent component analysis of functional magnetic resonance imaging data. J Magn Reson Imaging. 2004 Mar;19(3):365-8. PubMed PMID: 14994306; PubMed Central PMCID: PMC2265794.
  74. Schmithorst VJ, Holland SK. Event-related fMRI technique for auditory processing with hemodynamics unrelated to acoustic gradient noise. Magn Reson Med. 2004 Feb;51(2):399-402. PubMed PMID: 14755667.
  75. Schmithorst VJ, Holland SK. The effect of musical training on the neural correlates of math processing: a functional magnetic resonance imaging study in humans. Neurosci Lett. 2004 Jan 16;354(3):193-6. PubMed PMID: 14700729.
  76. Chiu C-YP, Schmithorst VJ, Holland SK, Choo DI. Event-related fMRI study of recognition of simulated CI speech. International Congress Series 2004; 1273:390-393.
  77. Holland SK, Choo DI, Ret JK, Hilbert L, Dunn RS, Schmithorst VJ. fMRI of severe to profoundly hearing-impaired infants and toddlers under sedation. International Congress Series 2004; 1273:383-386.
  78. Schmithorst VJ, Endorf RJ, Kulatunga S, Spelic DC, DiBianca FA, Rodriguez C, Zeman HD, Zhu Z, Giakos GC. Feasibility of Using a Kinestatic Charge Detector for Dual-Energy Chest Radiography. Journal of X-Ray Science and Technology 2004; 12:1-11.
  79. Schmithorst VJ, Endorf RJ, Kulatunga S, Spelic DC, DiBianca FA, Rodriguez C, Zeman HD, Zhu Z, Giakos GC. Optimization of a Dual-Energy Imaging Kinestatic Charge Detector for Chest Radiography. Journal of X-Ray Science and Technology 2004; 12:151-159.
  80. Wilke M, Schmithorst VJ, Holland SK. Normative pediatric brain data for spatial normalization and segmentation differs from standard adult data. Magn Reson Med. 2003 Oct;50(4):749-57. PubMed PMID: 14523961.
  81. Schmithorst VJ, Holland SK. The effect of musical training on music processing: a functional magnetic resonance imaging study in humans. Neurosci Lett. 2003 Sep 11;348(2):65-8. PubMed PMID: 12902019.
  82. Lamba M, Holland SK, Schmithorst V, Dardzinski B, d’Errico F, Nath R. Fast high-resolution 3D segmented echo planar imaging for dose mapping using a superheated emulsion chamber. Magn Reson Med. 2003 Apr;49(4):675-81. PubMed PMID: 12652538.
  83. Bickle J, Avison CM, Schmithorst VJ, Landreth A, Holland SK. Bridging the cognitive-cellular neuroscience gap empirically: a study combining physiology, modelling and fMRI. Journal of Experimental and Theoretical Artificial Intelligence 2003; 15:161-175.
  84. Wilke M, Holland SK, Myseros JS, Schmithorst VJ, Ball WS. Functional magnetic resonance imaging in pediatrics. Neuropediatrics 2003; 34:225-33.
  85. Byars AW, Holland SK, Strawsburg RH, Bommer W, Dunn RS, Schmithorst VJ, Plante E. Practical aspects of conducting large-scale functional magnetic resonance imaging studies in children. J Child Neurol. 2002 Dec;17(12):885-90. PubMed PMID: 12593460; PubMed Central PMCID: PMC1351160.
  86. Dardzinski BJ, Laor T, Schmithorst VJ, Klosterman L, Graham TB. Mapping T2 relaxation time in the pediatric knee: feasibility with a clinical 1.5-T MR imaging system. Radiology. 2002 Oct;225(1):233-9. PubMed PMID: 12355010.
  87. Wilke M, Schmithorst VJ, Holland SK. Assessment of spatial normalization of whole-brain magnetic resonance images in children. Hum Brain Mapp. 2002 Sep;17(1):48-60. PubMed PMID: 12203688.
  88. Schmithorst VJ, Wilke M. Differences in white matter architecture between musicians and non-musicians: a diffusion tensor imaging study. Neurosci Lett. 2002 Mar 15;321(1-2):57-60. PubMed PMID: 11872256.
  89. Schmithorst VJ, Dardzinski BJ. Automatic gradient preemphasis adjustment: a 15-minute journey to improved diffusion-weighted echo-planar imaging. Magn Reson Med. 2002 Jan;47(1):208-12. PubMed PMID: 11754462.
  90. Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK. Correlation of white matter diffusivity and anisotropy with age during childhood and adolescence: a cross-sectional diffusion-tensor MR imaging study. Radiology. 2002 Jan;222(1):212-8. PubMed PMID: 11756728; PubMed Central PMCID: PMC2268734.
  91. Pratt RG, Schmithorst VJ, Lamba M, Dardzinski BJ, d’Errico F, Nath R, Holland SK. System for automated magnetic resonance imaging of a superheated emulsion chamber for brachytheraphy dosimetry. Review of Scientific Instruments 2002; 73:2417-2421.
  92. Adler CM, Sax KW, Holland SK, Schmithorst V, Rosenberg L, Strakowski SM. Changes in neuronal activation with increasing attention demand in healthy volunteers: an fMRI study. Synapse. 2001 Dec 15;42(4):266-72. PubMed PMID: 11746725.
  93. Dardzinski BJ, Schmithorst VJ, Holland SK, Boivin GP, Imagawa T, Watanabe S, Lewis JM, Hirsch R. MR imaging of murine arthritis using ultrasmall superparamagnetic iron oxide particles. Magn Reson Imaging. 2001 Nov;19(9):1209-16. PubMed PMID: 11755731.
  94. Holland SK, Plante E, Weber Byars A, Strawsburg RH, Schmithorst VJ, Ball WS Jr. Normal fMRI brain activation patterns in children performing a verb generation task. Neuroimage. 2001 Oct;14(4):837-43. PubMed PMID: 11554802.
  95. Mosher TJ, Smith H, Dardzinski BJ, Schmithorst VJ, Smith MB. MR imaging and T2 mapping of femoral cartilage: in vivo determination of the magic angle effect. AJR Am J Roentgenol. 2001 Sep;177(3):665-9. PubMed PMID: 11517068.
  96. Smith HE, Mosher TJ, Dardzinski BJ, Collins BG, Collins CM, Yang QX, Schmithorst VJ, Smith MB. Spatial variation in cartilage T2 of the knee. J Magn Reson Imaging. 2001 Jul;14(1):50-5. PubMed PMID: 11436214.
  97. Schmithorst VJ, Dardzinski BJ, Holland SK. Simultaneous correction of ghost and geometric distortion artifacts in EPI using a multiecho reference scan. IEEE Trans Med Imaging. 2001 Jun;20(6):535-9. PubMed PMID: 11437113; PubMed Central PMCID: PMC1357361.
  98. Sze RW, Chan CB, Dardzinski BJ, Dunn S, Sanbe A, Schmithorst V, Robbins J, Holland SK, Strife JL. Three-dimensional MR microscopy of a transgenic mouse model of dilated cardiomyopathy. Pediatr Radiol. 2001 Feb;31(2):55-61. PubMed PMID: 11214686.

Reviews

  1. Schmithorst VJ, Yuan W. White matter development during adolescence as shown by diffusion MRI. Brain Cogn. 2010 Feb;72(1):16-25. Epub 2009 Jul 22. Review. PubMed PMID: 19628324.
  2. Vannest J, Karunanayaka PR, Schmithorst VJ, Szaflarski JP, Holland SK. Language networks in children: evidence from functional MRI studies. AJR Am J Roentgenol. 2009 May;192(5):1190-6. Review. PubMed PMID: 19380541; PubMed Central PMCID: PMC2791163.
  3. Wilke M, Holland SK, Myseros JS, Schmithorst VJ, Ball WS Jr. Functional magnetic resonance imaging in pediatrics. Neuropediatrics. 2003 Jun;34(5):225-33. Review. PubMed PMID: 14598227; PubMed Central PMCID: PMC1351215.

Conference Proceedings

  1. Schmithorst VJ, Panigrahy A, Adams P, Lo C. The Relation Between Nasal Nitric Oxide and Neurocognitive Outcome is Mediated by Regional Cerebral Blood Flow in Healthy Adolescents and Adolescents with Congenital Heart Disease.  In: ISMRM 27th Annual Meeting and Exhibition, Montreal, Canada, May 2019.
  2. Schmithorst VJ, Panigrahy A. Making Reconstruction WORK (Weighted Optimized Reconstruction of K-Space): Improving CNR/SNR via non-FFT Weighted Reconstruction.  In: ISMRM 27th Annual Meeting and Exhibition, Montreal, Canada, May 2019.
  3. Schmithorst VJ, Panigrahy A. Regional CBF differences underlie neurocognitive outcomes in older children with congenital heart disease: a voxelwise mediation analysis.  In: ISMRM 26th Annual Meeting and Exhibition, Paris, France, June 2018.
  4. Schmithorst VJ, Adams P, Lee V, Lo CW, Panigrahy A. Reduced Nasal Nitric Oxide Predicts Mismatched Alterations in Regional Cerebral Perfusion and Functional Brain Connectivity in Older Children with Congenital Heart Disease.  In: ISMRM 26th Annual Meeting and Exhibition, Paris, France, June 2018.
  5. Schmithorst VJ, Lee V, Panigrahy A. Asynchronous Local Analysis of simultaneous BOLD and ASL Multislice Acquisition (ALABAMA): Toward Whole-Brain Noninvasive Estimation of Resting-State Neuronal Vascular Coupling.  In: ISMRM 25th Annual Meeting and Exhibition, Honolulu, HI, April 2017.
  6. Schmithorst VJ, Lee V, Votava-Smith JK, Kim R, Ceschin R, Sulaiman S, Lai H, Johnson J, de Toledo JS, Bluml S, Paquette S, Panigrahy A. Reduced Functional Network Segregation is Associated with Reduced Structural Network Integration and Cost Pre-Operatively in Neonates with Complex Congenital Heart Disease.  In: ISMRM 25th Annual Meeting and Exhibition, Honolulu, HI, April 2017.
  7. Schmithorst VJ, Lee V, Lo C, Panigrahy A. Altered Functional Network Topology in Children with Complex Congenital Heart Disease is Associated with Reduced Regional Cerebral Perfusion and Cognitive Outcomes.  In: ISMRM 25th Annual Meeting and Exhibition, Honolulu, HI, April 2017.
  8. Lee V, Greenhalgh M, Reynolds WT, Verstynen TD, Yeh F-C, Lo CW, Schmithorst VJ, Panigrahy A. Multi-shell Multi-band Diffusion Imaging (MSMBDI) is more predictive of executive deficits in Preadolescents with Complex Congenital Heart Disease (CHD) compared to standard diffusion tensor imaging (DTI).  In: ISMRM 25th Annual Meeting and Exhibition, Honolulu, HI, April 2017.
  9. Lee VK, Panigrahy A, Schmithorst VJ, Chenevert T, Gagoski B, Qui D, LaViolette PS, Berman JI, Verstynen TD, Yeh F-C. Robustness of Local Connectome Fingerprint Explored: Using a Multi-center and Multi-vendor Study.  In: ISMRM 25th Annual Meeting and Exhibition, Honolulu, HI, April 2017.
  10. Lee VK, El-Ali AM, Zahner A, Vani K, Rajagopalan V, Gruss M, Adibi J, Schmithorst VJ, Panigrahy A. BOLD MR Imaging of Placenta in Congenital Heart Disease.  In: ISMRM 25th Annual Meeting and Exhibition, Honolulu, HI, April 2017.
  11. Schmithorst VJ, Lee V, Votava-Smith J, Sulaiman S, Ceschin R, Paquette L, Panigrahy A. Complex congenital heart defects in infants produce lasting decreases in functional network segregation.  In: ISMRM 24th Annual Meeting and Exhibition, Singapore, May 2016.
  12. Lee VK, Monsour M, Pathak S, Schmithorst VJ, Panigrahy A, Schneider W. HARDI acquisition in children using modular multiband multi-shell acquisition.  In: ISMRM 24th Annual Meeting and Exhibition, Singapore, May 2016.
  13. Lee VK, Schmithorst VJ, Votava-Smith J, Sulaiman S, Ceschin R, Paquette L, Panigrahy A. Disrupted resting-state connectivity in term neonates with complex CHD.  In: ISMRM 24th Annual Meeting and Exhibition, Singapore, May 2016.
  14. Schmithorst VJ, Votava-Smith J, Lee V, Rajagopalan V, Suleiman S, Paquette L, Panigrahy A. Decrease in functional network segregation in infants with congenital heart defects.  In: ISMRM 23rd Annual Meeting and Exhibition, Toronto, ON, Canada, May 2015.
  15. Schmithorst VJ, Panigrahy A, Wisnowski J, Walsh C, Bellinger D, Newburger J, Rivkin M. Global structural network topology mediates neurocognitive outcomes in children with congenital heart defects.  In: ISMRM 23rd Annual Meeting and Exhibition, Toronto, ON, Canada, May 2015.
  16. Schmithorst V, Lee V, Paquette L, Suleiman S, Votava-Smith J, Rajagopalan V, Panigrahy A. White matter microstructure and structural topology differences in neonatal congenital heart disease.  In: Organization for Human Brain Mapping 21st Annual Meeting, Honolulu, HI, June 2015.
  17. Schmithorst VJ, Wisnowski J, Panigrahy A. Sex Differences in Structural and Functional Network Topology are Present at Birth: A Multi-Modal Graph Theory Study.  In: ISMRM 22nd Annual Meeting and Exhibition, Milan, Italy, May 2014.
  18. Schmithorst VJ, Vannest J, Lee G, Hernandez-Garcia L, Plante E, Rajagopal A, Holland SK. What You See is Not What You Get: BOLD Signal Increases with Age in Children May Be the Result of Increased Neuronal-Vascular Coupling and not Increased Neuronal Activity.  In: ISMRM 22nd Annual Meeting and Exhibition, Milan, Italy, May 2014.
  19. Schmithorst VJ, Wisnowski J, Panigrahy A. Robustness of TBSS and VBM-like Voxelwise DTI Analyses.  In: Organization for Human Brain Mapping 19th Annual Meeting, Seattle, WA, June 16-20, 2013.
  20. Schmithorst V, Lee G, Hernandez-Garcia L, Vannest J, Plante E, Holland S. Increasing BOLD Effect with Age May Reflect Decreased Metabolic Demand: A Functional ASL/BOLD Study.  In: Organization for Human Brain Mapping 19th Annual Meeting, Seattle, WA, June 16-20, 2013.
  21. Schmithorst VJ, Hernandez-Garcia L, Vannest J, Rajagopal A, Lee G, Holland S. A double-excitation approach is the optimal for whole-brain ASL-BOLD acquisitions.  In: ISMRM 21th Annual Meeting and Exhibition, Salt Lake City, UT, April 20-26, 2013.
  22. Schmithorst VJ, Panigrahy A, Wisnowski J. DTI Correlates of Functional Brain Network Topology in a Pediatric Population.  In: ISMRM 21th Annual Meeting and Exhibition, Salt Lake City, UT, April 20-26, 2013.
  23. Schmithorst VJ, Holland S, Plante E. Unilateral hearing loss in children affects development of the default mode network.  In: ISMRM 21th Annual Meeting and Exhibition, Salt Lake City, UT, April 20-26, 2013.
  24. Schmithorst VJ, Wisnowski J. Panigrahy A. TBSS may be sub-optimal for detection of DTI parameter changes in crossing fiber regions.  In: ISMRM 21th Annual Meeting and Exhibition, Salt Lake City, UT, April 20-26, 2013.
  25. Schmithorst VJ, Holland SK, Keith RW. Unilateral Sensorineural Hearing Loss is Predicted by Reduced Mean Diffusivity in the Sublenticular Region of the Left Internal Capsule.  In: ISMRM 20th Annual Meeting & Exhibition, Melbourne, Australia, May 5-11, 2012.
  26. Schmithorst VJ, Farah RL, Keith RW. The right-ear advantage for dichotic listening of speech-related stimuli is predicted by both attentional and structural factors: results from machine-learning analysis of neuroimaging data.  In: ISMRM 20th Annual Meeting & Exhibition, Melbourne, Australia, May 5-11, 2012.
  27. Schmithorst VJ, Holland SK. A DTI Study of Children with Unilateral Sensorineural Hearing Loss.  In: Human Brain Mapping Annual Meeting, Quebec City, Quebec, Canada, June 26-30, 2011.
  28. Vannest J, Eaton K, Henkel D, Szaflarski J, Glauser T, Morita D, Schmithorst V, Byars A, Holland S. Atypical neural circuitry in children with Benign Epilepsy with Centro-Temporal Spikes.  In: Human Brain Mapping Annual Meeting, Quebec City, Quebec, Canada, June 26-30, 2011.
  29. Szaflarski J, Byars A, Jacola L, Schmithorst V, Altaye M, Schapiro M, Rajagopal A, Plante E, Holland S. Handedness and Language Lateralization in Children.  In: Human Brain Mapping Annual Meeting, Quebec City, Quebec, Canada, June 26-30, 2011.
  30. Henkel D, Eaton K, Holland S, Schmithorst V, Vannest J. The neural basis of linguistic prosody discrimination in healthy children and young adults.  In: Human Brain Mapping Annual Meeting, Quebec City, Quebec, Canada, June 26-30, 2011.
  31. Schmithorst VJ, Holland SK, Plante E. The neural basis for auditory processing disorders?  In: ISMRM 19th Annual Meeting & Exhibition, Montreal, Quebec, Canada, May 7-13, 2011.
  32. Schmithorst VJ, Holland SK. Between-group racial differences in the relation of brain function to intelligence.  In: ISMRM 19th Annual Meeting & Exhibition, Montreal, Quebec, Canada, May 7-13, 2011.
  33. Schmithorst VJ, Hernandez-Garcia L, Vannest J, Holland SK. A technique for obtaining simultaneous ASL/BOLD functional MRI contrast in the whole brain. In: Human Brain Mapping Annual Meeting, Barcelona, Spain, June 6-10, 2010.
  34. Schmithorst VJ, Holland SK. Different higher-order auditory processing tasks show differing correlations with white matter microstructure in normal-hearing children. In: ISMRM 18th Annual Scientific Meeting & Exhibition, Stockholm, Sweden, May 1-7, 2010.
  35. Schmithorst VJ, Holland SK. Cross-Modal Plasticity for Auditory Processing is Present in Normal-Hearing Children for Non-Speech Stimuli. In: ISMRM 18th Annual Scientific Meeting & Exhibition, Stockholm, Sweden, May 1-7, 2010.
  36. Schmithorst VJ, Holland SK. Dependence of Central Auditory Processing on White Matter Organization as Investigated by Diffusion Tensor Imaging. In: American Society of Neuroradiology 47th Annual Meeting, Vancouver, BC, Canada, May 16-21, 2009.
  37. Schmithorst VJ, Holland SK. Investigating the Neural Basis Underlying Religious Belief Using fMRI. In: Human Brain Mapping Annual Meeting, San Francisco, CA, June 18-23, 2009.
  38. Schmithorst VJ, Vannest J, Holland SK. A Method for Fusion of fMRI Data with MEG Data from the Same Cognitive Task. In: Human Brain Mapping Annual Meeting, San Francisco, CA, June 18-23, 2009.
  39. Schmithorst VJ, Wiley SK. The Impact of Unilateral Sensorineural Hearing Loss in Children on Cortical Processing of Sound. In: 8th Annual Early Hearing Detection & Intervention Conference, Dallas, TX, March 9-10, 2009.
  40. Vannest J, Eaton K, Rasmussen J, Szaflarski JP, Szalewski K, Schmithorst VJ. fMRI Identified Left-Lateralized and Bilateral Language Functions in Children and Young Adults. In: Society for Pediatric Radiology 52nd Annual Meeting, Carlsbad, CA, April 22-25, 2009.
  41. Cecil K, Dietrich KN, Altaye M, Egelhoff JC, Brubaker CJ, Schmithorst VJ, Haynes EN, Wessel SD, Lanphear BP. Evaluating the effects of childhood lead exposure with proton MR spectroscopy and diffusion tensor imaging. In: Society for Pediatric Radiology 51st Annual Meeting, Scottsdale, AZ, May 5-9, 2008.
  42. Karunanayaka P, Holland SK, Schmithorst VJ, Plante EJ. Age-Related Connectivity Changes in FMRI Data from Children Performing a Covert Verb Generation Task. In: ISMRM 17th Annual Scientific Meeting & Exhibition, Toronto, ON, Canada, May 5-9, 2008.
  43. Schmithorst VJ, Holland SK. Differences in White Matter Microstructure between Children with Right and Left Unilateral Sensorineural Hearing Loss. In: ISMRM 17th Annual Scientific Meeting & Exhibition, Toronto, ON, Canada, May 5-9, 2008.
  44. Schmithorst VJ, Holland SK. Higher-Order Contrast Functions Improve Performance of Independent Component Analysis of Functional MRI Data with Low Signal-to-Noise Ratio. In: ISMRM 17th Annual Scientific Meeting & Exhibition, Toronto, ON, Canada, May 5-9, 2008.
  45. Schmithorst VJ, Holland SK. An Improved Algorithm for Data Reduction Prior to Independent Component Analysis of Functional MRI Data in the Presence of Colored Noise and Low Source Signal-to-Noise Ratio. In: ISMRM 17th Annual Scientific Meeting & Exhibition, Toronto, ON, Canada, May 5-9, 2008.
  46. Schmithorst VJ, Holland SK. Networks Used for Interpretation of Speech-In-Noise in Children with Unilateral Sensorineural Hearing Loss. In: ISMRM 17th Annual Scientific Meeting & Exhibition, Toronto, ON, Canada, May 5-9, 2008.
  47. Schmithorst VJ, Holland SK. Networks Utilized for Receptive Speech in Children with Right and Left Unilateral Sensorineural Hearing Loss. In: ISMRM 17th Annual Scientific Meeting & Exhibition, Toronto, ON, Canada, May 5-9, 2008.
  48. Vannest J, Karunanayaka P, Altaye M, Schmithorst VJ, Plante E, Holland SK. Comparison between Event-Related and Block-Periodic fMRI Data from a Story Processing Task in Children. In: Society for Pediatric Radiology 51st Annual Meeting, Scottsdale, AZ, May 5-9, 2008.
  49. Vannest J, Rasmussen J, Schmithorst VJ, Karunanayaka P, Byars AW, Holland SK. Neural Activity in Language Areas Reflects Verb Generation Performance in Children. In: Society for Pediatric Radiology 51st Annual Meeting, Scottsdale, AZ, May 5-9, 2008.
  50. Chalfonte-Evans M, Schmithorst VJ, Hickey F, Patterson B, Hotze S, Holland SK, Schapiro MB. FMRI reveals atypical activation in persons with Down syndrome during a story processing task. In: Organization for Human Brain Mapping 13th Annual Meeting, Chicago, IL, June 10-14, 2007.
  51. Karunanayaka P, Holland S, Mecoli M, Egelhoff JC, Schmithorst V, Altaye M, Brown D, Choo DI. FMRI Shows Differences in Auditory Activation between Infants with Normal Hearing and Bilateral Sensorineural Deafness. In: Organization for Human Brain Mapping 13th Annual Meeting, Chicago, IL, June 10-14, 2007.
  52. Karunanayaka P, Holland S, Mecoli M, Egelhoff JC, Schmithorst V, Altaye M, Brown D, Choo DI. FMRI Shows Differences in Auditory Activation between Infants with Normal Hearing and Bilateral Sensorineural Deafness. In: 11th International Conference on Cochlear Implants in Children, Charlotte, NC, April 11-14, 2007.
  53. Karunanayaka PR, Schmithorst VJ, Holland SK. Cognitive Modules Utilized for Covert Verb Generation in Children: A Functional Magnetic Resonance Imaging Study. In: ISMRM 15th Scientific Meeting and Exhibition, Berlin, Germany, May 21-25, 2007.
  54. Mecoli M, Egelhoff JC, Karunanayaka P, Schmithorst VJ, Holland S. Heschl’s gyrus volume in hearing impaired and normal hearing infants. In: Organization for Human Brain Mapping 13th Annual Meeting, Chicago, IL, June 10-14, 2007.
  55. Mecoli M, Holland S, Karunanayaka P, Egelhoff JC, Schmithorst VJ, Altaye M, Cahill L, Brown D, Choo DI. Correlations of fMRI Activation in Auditory Cortex and Hearing Levels in Infants with Congenital Hearing Impairment Prior to Cochlear Implantation. In: 11th International Conference on Cochlear Implants in Children, Charlotte, NC, April 11-14, 2007.
  56. Schmithorst VJ, Holland SK. Differences Between Boys and Girls in the Development of Neuroanatomical Functional Connectivity Underlying Intelligence Found Using Bayesian Connectivity Analysis. In: ISMRM 15th Scientific Meeting and Exhibition, Berlin, Germany, May 21-25, 2007.
  57. Schmithorst VJ, Holland SK. Incorporating between-subjects analysis into ICA decomposition of fMRI data. In: Organization for Human Brain Mapping 13th Annual Meeting, Chicago, IL, June 10-14, 2007.
  58. Schmithorst VJ, Keith R, Brown D, Holland SK. The Neural Correlates of Interpreting Speech-In-Noise in Children with Unilateral Sensorineural Hearing Loss Investigated Using a Functional MRI Paradigm with Silent Gradient Intervals. In: ISMRM 15th Scientific Meeting and Exhibition, Berlin, Germany, May 21-25, 2007.
  59. Vannest J, Karunanayaka PR, Altaye M, Schmithorst VJ, Plante E, Eaton K, Holland SK. Comparison between event-related and block-periodic fMRI data from a story processing task in children. In: Organization for Human Brain Mapping 13th Annual Meeting, Chicago, IL, June 10-14, 2007.
  60. Jacola LM, Schapiro M, Patterson B, Hickey F, Chalfonte-Evans M, Schmithorst VJ, Byars AW, Hotze S, Holland SK. FMRI reveals altered patterns of brain activation during language processing in persons with Down syndrome. In: Organization for Human Brain Mapping 12th Annual Meeting, Florence, Italy, June, 2006.
  61. Kaimal V, Holland SK, Schmithorst VJ, Qi X. MR Detection of Tumor Cells Labeled with USPIO using DOPS Liposomes. In: ISMRM 14th Scientific Meeting & Exhibition, Seattle, WA, May 6-12, 2006.
  62. Karunanayaka P, Holland SK, Schmithorst VJ, Solodkin A, Plante E. Age Related Connectivity Changes in fMRI Data from Children Listening to Stories. In: ISMRM 14th Scientific Meeting & Exhibition, Seattle, WA, May 6-12, 2006.
  63. Karunanayaka PR, Holland S, Schmithorst VJ, Solodkin A, Altaye M, Plante E. Functional connectivity among cognitive modules utilized for narrative story comprehension. In: Organization for Human Brain Mapping 12th Annual Meeting, Florence, Italy, June, 2006.
  64. Karunanayaka PR, Holland SK, Schmithorst VJ, Solodkin A, Plante E. Age related connectivity changes in fMRI data from children performing a narrative story comprehension task. In: Organization for Human Brain Mapping 12th Annual Meeting, Florence, Italy, June, 2006.
  65. Rajagopal A, O’Brien KJ, Schmithorst VJ, Kalra M, Dardzinski BJ. Automatic Segmentation of Adipose Tissue Distribution in Childhood Obesity. In: ISMRM 14th Scientific Meeting & Exhibition, Seattle, WA, May 6-12, 2006.
  66. Schmithorst VJ, Altaye M, Byars AW, Ret J, Plante E, Holland SK. Longitudinal fMRI study of narrative comprehension in children ages 5-11. In: Organization for Human Brain Mapping 12th Annual Meeting, Florence, Italy, June, 2006.
  67. Schmithorst VJ, Altaye M, Hilbert L, Patel A, Brown D, Eads E, Cahill L, Choo DI. Auditory activation in sedated hearing impaired infants. In: Organization for Human Brain Mapping 12th Annual Meeting, Florence, Italy, June, 2006.
  68. Schmithorst VJ, Altes TA, Young LR, Bissler JJ, Franz DN, McCormack FX, Brody A. A New Method for Quantitative Chest CT: Results in Lymphangioleiomyomatosis (LAM). In: American Thoracic Society Annual Meeting, San Diego, CA, May, 2006.
  69. Schmithorst VJ, DiFrancesco M, Dardzinski BJ, Holland SK. Sex Differences in White Matter Diffusion Anisotropy in the Normal Pediatric Population. In: ISMRM 14th Scientific Meeting & Exhibition, Seattle, WA, May 6-12, 2006.
  70. Schmithorst VJ, Holland SK. A Data-Driven Method for Analysis of Associated Time Courses Found from Group Independent Component Analysis. In: ISMRM 14th Scientific Meeting & Exhibition, Seattle, WA, May 6-12, 2006.
  71. Schmithorst VJ, Holland SK. The development of functional and effective connectivity for narrative processing in children investigated via functional MRI and Multivariate Autoregressive Modeling. In: ISMRM 14th Scientific Meeting & Exhibition, Seattle, WA, May 6-12, 2006.
  72. Schmithorst VJ, Holland SK. Differences between Boys and Girls in the Correlation of Functional Brain Connectivity and Intelligence. In: ISMRM 14th Scientific Meeting & Exhibition, Seattle, WA, May 6-12, 2006.
  73. Schmithorst VJ, Holland SK, Plante E. Object Identification and Lexical/Semantic Access in Children: A Functional Magnetic Resonance Imaging Study of Word-Picture Matching. In: Organization for Human Brain Mapping 12th Annual Meeting, Florence, Italy, June, 2006.
  74. Schmithorst VJ, Wilke M. A bootstrap approach for calculating lateralization indices in functional imaging data. In: Organization for Human Brain Mapping 12th Annual Meeting, Florence, Italy, June, 2006.
  75. Szaflarski JP, Schmithorst VJ, Altaye M, Byars AW, Ret J, Plante E, Holland SK. A longitudinal fMRI study of language development in children. In: 58th Annual Meeting of the American Academy of Neurology, San Diego, CA, April, 2006.
  76. Adler CM, Adams J, DelBello MP, Holland SK, Schmithorst VJ, Strakowski SM. Evidence of White Matter Pathology in First-Episode Manic Adolescents with Bipolar Disorder: A Diffusion Tensor Imaging Study. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  77. Adler CM, DelBello MP, Holland SK, Schmithorst VJ, Strakowski SM. Functional MRI Investigation of ADHD Comorbidity in Adolescent Bipolar Patients. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  78. Chiu C-YP, Cummings CM, Schmithorst VJ, Holland SK, Keith R. Sound Blending in the Brain: A Developmental fMRI Investigation. In: Biennial Meeting of the Society for Research in Child Development, Atlanta, GA, April, 2005.
  79. Chiu C-YP, Schmithorst VJ. Covert and Overt Sound-Blending in the Brain. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  80. Eliassen JC, Szaflarski JP, Holland SK, Schmithorst VJ, Shear P, Strakowski SM, Privitera MP. Compensatory processing outside medial temporal lobe during verbal recognition memory in patients with medial temporal lobe epilepsy (MTLE). In: 57th Annual Meeting of the American Academy of Neurology, Miami, FL, April, 2005.
  81. Patel A, Choo DI, Arjmand E, Karunanayaka P, Schmithorst VJ, Holland SK. fMRI and Outcome of Cochlear Implant in Infants. In: SENTAC, Baltimore, MD, December, 2005.
  82. Schmithorst VJ. Maximum a posteriori Independent Component Analysis (MAP-ICA): A Bayesian framework for incorporating prior information into ICA analyses of fMRI data. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  83. Schmithorst VJ, Holland SK. A longitudinal fMRI investigation of the development of sentential and lexical aspects of language processing in normal children. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  84. Schmithorst VJ, Holland SK. A method for generating voxelwise between-groups statistical inferences from fMRI data using Independent Component Analysis. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  85. Schmithorst VJ, Holland SK. Sex Differences in Associations of Brain Anatomical and Functional Connectivity with IQ in Children. In: International Society for Intelligence Research 6th Annual Conference, Albuquerque, NM, December 2, 2005.
  86. Schmithorst VJ, Holland SK, Dardzinski BJ. Sex differences in white matter microstructure in the developing brain. In: ISMRM Workshop on Methods for Quantitative Diffusion MRI of Human Brain, Lake Louise, AB, Canada, March 13-16, 2005.
  87. Szaflarski JP, Holland SK, Sands SF, Schmithorst VJ, Lee JH, Strakowski SM, Privitera MD, Eliassen JC. Searching for the source of alpha rhythm: EEG-triggered fMRI at 4T. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  88. Szaflarski JP, Holland SK, Schmithorst VJ, Privitera MD, Ficker DF, Cahill WT, Cavitt JL, Meckler JM, Morriss AB. Comprehensive fMRI language evaluation in epilepsy patients. In: Annual Meeting of the American Epilepsy Society and the American Clinical Neurophysiology Society, Washington, DC, December, 2005.
  89. Szaflarski JP, Osterhage J, Southers B, Holland SK, Sands SF, Schmithorst VJ, Privitera MP, Lee JH, Strakowski SM. Localization of alpha rhythm generators using EEG-triggered fMRI (EEG-fMRI) at 4T. In: 57th Annual Meeting of the American Academy of Neurology, Miami, FL, April, 2005.
  90. Yuan W, Holland SK, Szaflarski JP, Schmithorst VJ, Byars AW, Strawsburg RH. fMRI Shows Atypical Language Lateralization in Children with Epilepsy. In: ISMRM 13th Scientific Meeting, Miami, FL, May 9-13, 2005.
  91. Brody A, Altes T, Schmithorst V. Imaging Rare Lung Diseases. In: LAM Foundation Research Conference, Cincinnati, OH, March 26-28, 2004.
  92. Chiu C-YP, R. Brown D, Schmithorst VJ, Holland SK. Neurodevelopment of Episodic Memory Encoding. In: 32nd Annual International Neuropsychological Society Meeting, Baltimore, MD, February, 2004.
  93. Chiu C-YP, Holland SK, Schmithorst VJ, Choo DI. Event-Related fMRI study of Recognition of Simulated CI Speech. In: VIII International Cochlear Implant Conference, Indianapolis, IN, May 10-13, 2004.
  94. Holland SK, Choo DI, Schmithorst VJ, Ret JK, Hilbert L, Dunn RS, O’Brien KJ. fMRI in Hearing Impaired Children Under Sedation. In: ISMRM 12th Scientific Meeting, Kyoto, Japan, May 15-21, 2004.
  95. Schmithorst VJ. Hypothesis-Driven Independent Component Analysis (hICA): Incorporating Prior Knowledge About the Hemodynamic Response into ICA Analysis of fMRI Data. In: ISMRM 12th Annual Scientific Meeting, Kyoto, Japan, May 15-21, 2004.
  96. Schmithorst VJ. Spatially Thresholded Independent Component Analysis (sthICA): Generating Voxelwise Statistical Inferences from ICA Analysis of fMRI Data. In: ISMRM 12th Annual Scientific Meeting, Kyoto, Japan, May 15-21, 2004.
  97. Schmithorst VJ, Brody A, Altes T. Analysis of CT Imaging in the Treatment of Rare Lung Disease. In: LAM Foundation Research Conference, Cincinnati, OH, March 26-28, 2004.
  98. Sohn JH, Cecil KM, Dunn RS, Schmithorst VJ, Holland SK. Functional loss of angular gyrus in adolescents with early exposure to lead performing a verb generation task: An fMRI study. In: Human Brain Mapping, Budapest, Hungary, June 13-17, 2004.
  99. Szaflarski JP, Schmithorst VJ, Holland SK, Byars AW. An fMRI Study of Cerebral Language Lateralization in 121 Children and Adults. In: 56th American Academy of Neurology Annual Meeting, San Francisco, CA, April 24 – May 1, 2004.
  100. Thompson EA, Holland SK, Schmithorst VJ. Detecting Cortical Activations from fMRI Data Using a Recursive STAP Algorithm. In: IEEE International Symposium on Biomedical Imaging, Arlington, VA, April 15-18, 2004.
  101. Brown R, Chiu PC-Y, Schmithorst VJ, Holland SK, Dunn RS. Episodic memory development: a functional magnetic imaging investigation. In: Society for Research in Child Development Biennial Meeting, Tampa, FL, April 24-27, 2003.
  102. Holland SK, Choo DI, Ret JK, Hilbert L, Dunn RS, O’Brien KJ, Schmithorst VJ. FMRI of Hearing Impaired Children Prior to Cochlear Implantation. In: 9th Symposium on Cochlear Implants in Children, Baltimore, MD, April, 2003.
  103. Plante E, Schmithorst VJ, Holland SK. Sex differences in the activation of language cortex during childhood. In: Arizona Alzheimer’s Research Center Annual Meeting, Phoenix, AZ, 2003.
  104. Schapiro MB, Wakefield JL, Byars AW, Schmithorst VJ, Strawsburg RH, Holland SK. Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke. In: 32nd Annual Meeting of Child Neurology Society, Miami Beach, FL, October 1-4, 2003.
  105. Schmithorst VJ, Holland S. A Comparison of Three Methods for Generating Group Statistical Inferences from Independent Component Analysis of fMRI Data. In: ISMRM 11th Scientific Meeting, Toronto, ON, July 10-16, 2003.
  106. Schmithorst VJ, Holland SK. Hemodynamics Unrelated to Sounds from Hardware (HUSH): A Completely Silent Event-Related fMRI Technique. In: ISMRM 11th Scientific Meeting, Toronto, ON, July 10-16, 2003.
  107. Schmithorst VJ, Holland SK. Neural Networks for Language Processing Determined via Group Independent Component Analysis Performed Simultaneously on fMRI Data from Separate Tasks. In: ISMRM 11th Scientific Meeting, Toronto, ON, July 10-16, 2003.
  108. Bickle J, Holland SK, Schmithorst VJ, Avison M. Predictions Derived from a Neurocomputational Model of Sequential Processing in Frontal Regions using FMRI. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  109. Brody A, Dardzinski BJ, Schmithorst VJ, Baginski S. Fractal Analysis of High Resolution Computed Tomography in Young Cystic Fibrosis Patients Correlates Well with Pulmonary Function Test. In: American Thoracic Society Conference, 2002.
  110. Dardzinski B, Laor T, Schmithorst VJ, Graham TB. Dynamic Contrast Enhancement Patterns in the Knee of Children with JRA. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  111. Dardzinski B, Schmithorst VJ, Mosher TJ, Smith MB. Cartilage Warping: A Technique for Inter-Subject Comparison of T2 Relaxation Time. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  112. Holland SK, Plante E, Weber Byars A, Schmithorst VJ, Wilke M, Arlinghaus LR, Frey JR. Mapping Language Development in Normal Children Using FMRI at 3T. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  113. Schapiro MB, Holland SK, Schmithorst VJ, Wilke M, Byars AW, Strawsburg RH. Functional magnetic resonance imaging (fMRI) brain activation increases with age in children performing a finger tapping task. In: Ann Neurol, 2002.
  114. Schapiro MB, Holland SK, Schmithorst VJ, Wilke M, Byars AW, Strawsburg RH. Functional Magnetic Resonance Imaging Brain Activation Increases with Age in Children Performing a Finger Tapping Task. In: Child Neurology Society, 2002.
  115. Schmithorst VJ, Holland SK. Separate Neural Networks for Language Processing using Hypothesis-Driven Independent Component Analysis. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  116. Schmithorst VJ, Holland SK. Multiple Networks Recruited during a Story Processing Task found using Group Inferences Across Subjects from Independent Component Analysis. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  117. Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK. IQ Correlates with Diffusion Tensor Imaging Parameters in Normal Children. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  118. Szaflarski J, Holland SK, Shear P, Schmithorst VJ, Strakowski SM, Privitera M. Using different fMRI language and memory tasks in healthy adults at 3T. In: 5th European Conference on Epileptology, Madrid, Spain, October 2002.
  119. Thompson EA, Holland SK, Schmithorst VJ. Detecting Cortical Activities from fMRI Data using the STAP Algorithm. In: IEEE ICIP, Rochester, NY, 2002.
  120. Wilke M, Schmithorst VJ, Byars AW, Strawsburg RH, Holland SK. Changes in the language lateralization index with age as detected by functional MRI in normal children. In: Neuropediatrics, 2002.
  121. Wilke M, Schmithorst VJ, Dardzinski BJ, Holland SK. Correlation of white matter diffusion properties with age in childhood as detected by diffusion tensor imaging. In: Neuropediatrics, 2002.
  122. Wilke M, Schmithorst VJ, Holland SK. Construction of gender-specific pediatric templates for spatial normalization within SPM99. In: ISMRM 10th Scientific Meeting, Honolulu, HI, May 18-24, 2002.
  123. Wilke M, Schmithorst VJ, Holland SK. Construction of a pediatric template for use within SPM99. In: Child’s Nervous System, Euro. Soc. Mag. Res. Neurol., London, UK, March 2002.
  124. Wilke M, Schmithorst VJ, Holland SK. Adding a functional component to structural neuroimaging: normal human brain development as assessed by statistical parametric mapping. In: Neuropediatrics, 2002.
  125. Adler CM, Strakowski SM, Holland SK, DelBello MP, Schmithorst V, Tuchfarber MJ. Neurophysiology of Working Memory in Bipolar Disorder. In: Society of Biological Psychiatry Annual Meeting, 2001.
  126. Adler CM, Strakowski SM, Holland SK, Schmithorst VJ, Enseleit S. An fMRI study of working memory in bipolar disorder. In: Proc. Society of Biological Psychiatry, New Orleans, LA, 2001.
  127. Bickle JW, C. Avison M, Schmithorst VJ, Holland SK. Cellular Mechanisms of sequential Processing in Frontal Regions Revealed Using a Combined Computational-fMRI Methodology. In: World Congress on Neuroinformatics, Vienna, Austria, September 2001.
  128. Dardzinski BJ, Schmithorst VJ, Holland SK, Boivin GP, Imagawa T, Wantanabe S, Hirsch R, Lewis JM. Magnetic Resonance Microimaging of Murine Arthritis. In: ISMRM 9th Scientific Meeting, Glasgow, Scotland, UK, April 2001.
  129. Holland SK, Plante E, Weber-Byars AS, Schmithorst VJ, Strawsburg RH. Functional MRI of Normal Language Development. In: Human Brain Mapping 7th Annual Meeting, Brighton, UK, June 10-14, 2001.
  130. Mosher TJ, Smith H, Collins CM, Dardzinski BJ, Schmithorst VJ, Smith MB. Reproducibility of In Vivo Cartilage T2 Profiles: Implication for Longitudinal Studies. In: ISMRM 9th Scientific Meeting, Glasgow, Scotland, UK, April 2001.
  131. Schmithorst VJ, Dardzinski BJ. Automatic gradient pre-emphasis adjustment. In: Minnesota Workshop on High Field MR Imaging and Spectroscopy, Minneapolis, MN, October 5-6, 2001.
  132. Strakowski SM, Adler CM, Holland SK, DelBello MP, Schmithorst V. Neural Activation During Facial Affect Recognition in Euthymic Bipolar Disorder. In: Society of Biological Psychiatry Annual Meeting, 2001.
  133. Wilke M, Schmithorst VJ, Holland SK. Age dependency of linear spatial normalization in childhood. In: Minnesota Workshop on MR Imaging of Brain Function, Minneapolis, MN, October 7-8, 2001.
  134. Dardzinski BJ, Laor T, Schmithorst VJ, Klosterman LA. Spatial Variation of Cartilage T2 in the Immature Pediatric Knee. In: ISMRM Eighth Scientific Meeting, Denver, CO, April 1-7, 2000.
  135. Lamba, Holland SK, D’Errico F, Dardzinski BJ, Schmithorst VJ, Nath R. 3D Segmented Echo Planar Imaging for Fast High Resolution Dose Mapping in a Superheated Emulsion Chamber. In: World Congress on Med. Physics and Biomedical Engineering, Chicago, IL, 2000.
  136. Mosher TJ, Smith H, Dardzinski BJ, Schmithorst VJ, Smith MB. Effect of Orientation on Cartilage T2: In Vivo Determination of the Magic Angle Effect Using T2-Mapping of Femoral Cartilage. In: ISMRM Eighth Scientific Meeting, Denver, CO, April 1-7, 2000.
  137. Plante E, Holland SK, Weber AM, Strawsburg RH, Schmithorst VJ, Ball WS. Functional MRI of Normal Language Development. In: Symposium on Research in Child Language Disorders, Madison, WI, June 2000.
  138. Schmithorst VJ, Dardzinski BJ, Holland SK. Composite Diffusion Tensor Maps in the Pediatric Brain. In: Gordon Research Conference on In Vivo Magnetic Resonance, Andover, NH, August 2000.
  139. Smith H, Mosher TJ, Collins BG, Collins CM, Yang QX, Dardzinski BJ, Schmithorst VJ. Spatial Variation in Cartilage T2 of the Knee Joint. In: ISMRM Eighth Scientific Meeting, Denver, CO, April 1-7, 2000.
  140. Dardzinski BJ, Laor T, Schmithorst VJ, Klosterman LA, Tan S. Mapping the Spatial Variation of T2 in the Pediatric Knee. In: 42nd Annual Meeting of the Society for Pediatric Radiology, Vancouver, BC, Canada, May 14-17, 1999.
  141. Dardzinski BJ, Schmithorst VJ, Mosher TJ. Entropy Mapping of Articular Cartilage. In: ISMRM Seventh Scientific Meeting, Philadelphia, PA, 1999.
  142. Dardzinski BJ, Schmithorst VJ, Mosher TJ, Smith MB. T1-T2 Comparison in Adult Articular Cartilage. In: ISMRM Seventh Scientific Meeting, Philadelphia, PA, May 22-28, 1999.
  143. Holland SK, Strawsburg RH, Weber AM, Dunn RS, Schmithorst VJ, Ball WS Jr. Differences in fMRI Language Activation Patterns between Audio and Visual Presentation of the Same Verb Generation Task in Pediatric Epilepsy Patients. In: ISMRM 7th Scientific Meeting, Philadelphia, PA, May 1999.
  144. Klosterman LA, Schmithorst VJ, Tan S, Dardzinski BJ. T2 Measurements in Adult Patellar Cartilage at 1.5 and 3.0 Tesla. In: ISMRM Seventh Scientific Meeting, Philadelphia, PA, May 22-28, 1999.
  145. Strawsburg RH, Weber AM, Holland SK, Schmithorst VJ, Dunn RS, Ball WS. Comparison of Auditory and Visual Stimulation Functional MRI Paradigms for Language Lateralization in Pediatric Patients. In: Epilepsia, 40(S2), 23rd International Epilepsy Congress., Czech Republic, 1999.
  146. Holland SK, Strawsburg RH, Weber AM, Dunn RS, Schmithorst VJ and Ball WS. fMRI of Language Distributions in Pediatric Epilepsy Patients. In: SNR XVI/ASNR, Philadelphia, PA, 1998.

Other Publications

  1. Schmithorst VJ. Functional connectivity in the brain and human intelligence. Behav Brain Sci 2007; 30:169-170. Commentary on: Jung RE, Haier RJ. The Parieto-Frontal Integration Theory (P-FIT) of Intelligence: Converging Neuroimaging Evidence. Behav Brain Sci 2007; 30:135-154.

PROFESSIONAL ACTIVITIES

TEACHING

Assisted (with Dr. Scott Holland) in the teaching of courses in the Biomedical Engineering Department at the University of Cincinnati (BME 712: Advanced Topics in MRI).  Lectures given on topics including Fourier Transforms, Image Reconstruction, Fast Imaging, Basic Principles of BOLD Imaging, Diffusion Tensor Imaging.

Given lectures on use of image processing software (authored by myself) including a series of four lectures for interested researchers in the Summer of 2009.  Also assisted on an individual/as-needed basis.

Mentored post-doctoral research associates Prasanna Karunanayaka, Ph.D., and Weihong Yuan, Ph.D, at Cincinnati Children’s Hospital.  Dr. Yuan subsequently obtained a faculty position at Cincinnati Children’s Hospital.

Mentored Pediatric Otolaryngology – Head & Neck Surgery fellow Dr. Evan Probst.  A paper “Neuroanatomical differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging” with Dr. Probst as first author won 2nd prize at the American Society of Pediatric Otolaryngology meeting in Seattle, WA in Spring 2009.

Co-chaired the Ph.D. dissertation committee of Lori Kroeger at the University of Cincinnati.  Her dissertation research investigated the neural correlates of math processing in children with math disabilities, as compared with typically achieving children, using functional MRI.

Member of dissertation committee of Rola Farah at the University of Cincinnati.  Her dissertation research investigated differences in brain structure and function related to auditory processing in children with atypical “left-ear advantage” on dichotic listening tasks, as compared with normal children who exhibit “right-ear advantage”.

 

 

RESEARCH

Current Grant Support

Grant Number Grant Title Role in Project % Effort Source Project Dates
R01 HL138818-01 SVR III: Brain Connectome and Neurodevelopmental Outcomes Co-I 15 NIH 8/1/15 – 7/31/20
R01 MH115466 Caregiving Effects on the Early Development of Infant Brain-Behavior Relationships Co-I 10 NIH 7/1/18-6/30/23
R01 ES016531 Communities Actively Researching Exposure Study (CARES) Subcontract P.I. 20 NIH 9/1/16 – 8/31/21
TBD SVR III: Brain Connectome and Neurodevelopmental Outcomes Supplement Co-I 2 SPR 1/1/17 – 1/31/20
PR151098 Cilia Dysfunction and Poor Neurodevelopmental Outcomes in Congenital Heart Disease Co-I 5 DOD 9/1/16 – 8/31/19

 

Prior Grant Support

Grant Number Grant Title Role in Project % Effort Source Project Dates
HHSN27520090001BC Pediatric Functional Neuroimaging Research Network Co-Investigator 75 National Institutes of Health  – National Institute for Child Health and Development $6,431,914
K25DC008110 Cortical Reorganization in Children with Unilateral Sensorineural Hearing Loss Principal Investigator 50 National Institutes of Health – National Institute for Deafness and other Communication DIsorders 05/06 – 04/11
R01 HD038578 fMRI of Normal Language Development in Children Co-Investigator

(P.I.: Scott Holland)

 ~25 National Institutes of Health  – National Institute for Child Health and Development 2/00 – 1/10
R01 DC07186 fMRI, Genes and Outcome for Cochlear Implants in Infants Co-Investigator

(P.I.: Scott Holland)

 ~25 National Institutes of Health – National Institute for Deafness and other Communication Disorders 12/04 – 11/09
R03 DC006771 fMRI Studies of Neural Development in Speech Recognition Subcontract P.I.  (Main P.I.: Peter Chiu) ~10 National Institutes of Health – National Institute for Deafness and other Communication Disorders 9/05 – 8/08

 

 

 

 

Seminars and Invited Lectures:

“FMRI and Independent Component Analysis of Normal Language Development in Children” presented at Purdue University, November, 2004.

“Investigating the Development of the Brain via Neuroimaging” presented at Ohio State University, February, 2005.

“Functional MRI: Bridging Physics and Physiology” presented at University of Cincinnati Department of Physics, September, 2005.

“Boys, Girls, Brains, Intelligence, and Hearing” presented at University of Kentucky, November, 2007.

“The Network is the Brain: Network identification and connectivity modeling in the pediatric brain” presented at University of Arizona – Tucson, February, 2008.

“Imaging the Pediatric Brain: The Relevance of Functional MRI to Management of Children with Hearing Loss” presented at the Society for Ear, Nose, and Throat Advances in Children (SENTAC) Annual Meeting, Cincinnati, OH, December, 2010.

“Beyond correlations and blobology: what neuroimaging can really tell us about cognitive function” presented at Carnegie Mellon University, April, 2014.

Other Research Related Activities:

Journal referee for:  Magnetic Resonance in Medicine, Journal of Magnetic Resonance Imaging, Magnetic Resonance Imaging, NeuroImage, Human Brain Mapping, Brain and Cognition, Magnetic Resonance Materials in Physics Biology and Medicine, Child Neuropsychology, Frontiers in Neuroscience.

NIH Study Sections Reviewed for: Surgical Sciences, Biomedical Imaging and Bioengineering IRG  SRO: Behrouz Shabestari, Ph.D.  (2005-2008)

Extra-mural grant reviewing: Action on Hearing Loss (formerly RNID) in the United Kingdom.

 

CURRENT RESEARCH INTERESTS:

 

The role of the cerebral vasculature (“neuro-vascular unit”) in normal cognitive function and pathology.  The vasculature in the brain is intricately connected to neurons and synapses in the brain (the “neurovascular unit”) using neurotransmitters such as nitric oxide as well as astrocytes, which contact blood vessels.  Aberrant NVU function may therefore play a role in adverse neurocognitive outcomes both in apparently normal as well as pathologic populations.  I am now investigating NVU function and its relation to cognition on populations such as patients with congenital heart disease.  This research holds out the exciting promise that NVU function may in fact be modifiable.

 

The relation of brain connectivity and topology to normal cognitive function and pathology.  Subtle differences in brain connectivity (rather than gross differences in morphology) are thought to underlie many disorders such as schizophrenia or autism.  I am now collaborating on several projects which are investigating whether subtle differences in brain network topology (as determined using sophisticated graph analysis techniques) may underlie adverse neurocognitive outcomes in pathologies such as preterm birth and congenital heart disease (CHD).  In both these populations, the quality of medical care has increased in recent decades, leading to much lower mortality rates.  However, adverse neurocognitive and behavioral outcomes have also been documented.  Our research demonstrates the potential of measures of topology to be potent biomarkers for neurocognitive outcome.

 

Optimization of MRI acquisition and reconstruction procedures.  Procedures for acquiring and reconstructing MRI data (developed in large part in the 1980s) have not kept pace with advances in computing power in recent years.  Improved MRI hardware also provides the promise of much improved MR images.  I am researching using clinically determined feature sets in order to provide a sparse basis upon which optimal acquisition and reconstruction strategies may be based.  Fast acquisition/reconstruction techniques which train mainly on normal images risk losing information relevant to clinicians.